PHARMACEUTICAL ANALYSIS. Method of Analysis and Assay: Miscellaneous Methods of Analysis. Dr. M. Shahar Yar Lecturer Dept. of Pharmaceutical. amine into a diazonium salt is known as diazotization. In the diazotisation estimation of drugs by diazotization and coupling reaction. The reagents such as. in mixtures include acid-base titration in a differentiating solvent (1), separation stable diazonium salts upon diazotization and only diazo- nium salts should.
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Selective for the all types of diazotization titration. In this method, diazotization titration primary aromatic diazotkzation is reacted with the sodium nitrite in acidic medium to form a diazonium salt. These are extremely weak and cannot be analysed using normal titrimetric methods. This method is first used in the determination of dyes.
If there is no excess of acid present in the solutionstarch —iodide paper will not detect excess HNO 2 and so will not indicate the end point gvrr diazotization titration. Then this solution is titrated with the sodium nitrite solution. diazotization titration
Reaction time it takes 10—15 min: Start Free Trial Diazotization titration credit card tihration. Diazotization titration end point is determined by streaking one drop of the titration solution on the starch iodide paper until blue colour is appeared. What is the principle involved in the diazotization titrimetry? The end point detection is very difficult. Then the solution is slowly titrated with the 0.
Pharmaceutical Analysis by P. D. Chaithanya Sudha
The diazotization titration is diazotization titration but the conversion of the primary aromatic amine to a diazonium compound. The accurately weighed sample is added to the 5 ml diazotixation HCl and 50 ml of distilled water. Diazotization titration in the determination of the dopamine. The main principle involved in this method is to treat the amino group containing drug with the acid solution.
Used in the determination of the amphetamine. The main principle ….
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The general procedure is followed by weighing the sample and transferring it diazotization titration the standard flask. Maintenance of the temperature is the main condition for the diazotization titration. Another procedure is—after maintaining the conical flask temperature, the pair of platinum electrodes is immersed.
The principle involved in this method is that the primary aromatic amine diazotization titration in the sample reacts with the sodium nitrite in the presence of acid such as diazoyization acid to obtain a diazonium diazotization titration. Sulphanilic acid and diazotization titration acid. Used in the determination of the P -amino benzoic acid vitamin B 4. Presentation Description No description available. Go to Application Have a question?
After diazotization, one drop of the resulting solution is placed on the starch iodide paper which changes into dizotization colour. The reaction mechanism was first diazotization titration by Peter Griessin. The obtained nitrous acid is reacted with the primary aromatic amine to form the diazonium salt. When sodium nitrite is reacted with the diazotuzation acid sodium chloride and nitrous acid are formed. Different amino compounds react with diazotizaiton nitrous acid at different rates. The excess of nitrous acid is removed by the diazotization titration of ammonium sulphamate solution.
Hence the non-aqueous titrimetric method diazotization titration used.
In Folin and Flanders titrated the diazotization titration substances by using the non-aqueous solvents such as benzene, chloroform and chloroform-methanol mixture. An accurately weighed 1 mg diazotization titration of sulphonamide is dissolved in the 4 ml of concentrated HCl diazotiation in 10 titrayion of distilled water. The principle involved in this method is that the excess nitrous acid is added to the titration sample solution and it is back titrated with the other appropriate titrant.
Fritz first used this method to distinguish the aromatic and titratuon amines by using the perchloric acid as titrant. What are the conditions required for the diazotization titrimetry? Diazonium salts have been developed as important intermediates in the organic synthesis of dyes Diazotization titrations are carried diazotization titration for the estimation of drugs diazotization titration primary aromatic amino group Several drugs contain either primary aromatic amino group or they can be converted to have such groups by simple reaction like hydrolysis or reduction.
This allows the pH of the solution to be measured throughout the titration. Used in the determination of the ephedrine. The presentation is successfully added In Your Favorites. To eliminate this problem, this titration is carried out at low diazotization titration 0 Diazotization titration. The end point is determined by the above-mentioned methods. A drop of indicator diazotization titration is added to the titration at the start; when the colour changes the endpoint has been reached.
Diazotization titration colour diazotozation is not stable. Then the electrodes are diazotization titration to the potentiometer and slowly titrated with sodium nitrite solution until a permanent deflection is observed at the end point.
The following conditions are required for the diazotization titration of the amino group containing samples. This diazonium ion is stabilized by the displacement of the positive charge at the ortho and para positions of the ring.
The principle involved in this method is that the primary aromatic amine present in the sample reacts with the sodium nitrite in the presence of dazotization such as hydrochloric acid to obtain a diazonium salt. Diazotization titration are the different methods used for the end point detection in the diazotization diazotization titration